Mu mujyi wa Los Angeles, umuhanzi w’indirimbo witwa Dave Seville ahura n’akaga k’ubuzima no kutemerwa n’abashoramari. Ariko ibintu bihinduka igihe ahura n’udusimba dutatu twihariye—Alvin, Simon, na Theodore—utunyamaswa dushobora kuririmba mu buryo butangaje. Dave abaha icumbi, bo bakamufasha mu buhanzi bwe, maze bahinduka itsinda rikunzwe cyane.

Ariko uko izina n’amafaranga byiyongera, ubucuti bwabo buragerwa ku munzani. Umuyobozi w’inzu y’umuziki ashaka kubatandukanya kugira ngo ababyaze umusaruro. Alvin n’abo bavukana bagomba guhitamo hagati y’ubwamamare n’umuryango, naho Dave agasobanukirwa agaciro k’urukundo n’ubucuti kurusha amafaranga.