Mu mwaka wa 1942, ubwo isi yari mu ntambara ya kabiri y’isi yose, Steve Rogers, umusore w’intege nke ariko w’umutima ukomeye, yifuzaga kwinjira mu gisirikare cy’Amerika. Ariko kubera uburwayi n’umubiri woroshye, arahakirwa kenshi.

Ibyo bihinduka ubwo Dr. Abraham Erskine amutoranya mu mushinga w’ibanga witwa Project Rebirth, ugamije gukora abasirikare b’intangarugero. Steve ahabwa serumu y’intwari, igahindura umubiri we ukaba uw’umusirikare w’igitangaza—aba Captain America. Nyuma y’igeragezwa, Dr. Erskine aricwa n’umukozi wa HYDRA, ishami ry’ibanga ry’Abanazi riyobowe na Johann Schmidt, uzwi nka Red Skull. Steve Rogers asigara ari we wenyine wahawe serumu, agahinduka intwari y’igihugu.

Mu ntangiriro, akoreshwa mu bikorwa byo kwamamaza intambara, ariko nyuma y’uko itsinda ry’inshuti ze rifashwe mpiri, Steve afata icyemezo cyo kujya kubarokora. Aho niho atangira urugamba rwe nyarwo, arwanya Red Skull n’umushinga we wo kwigarurira isi akoresheje Tesseract, ikintu gifite imbaraga zidasanzwe.