In 1992 Bogota, a little girl (Amandla Stenberg) watches crime lord Don Luis (Beto Benites) and his henchman Marco (Jordi Mollà) murder her parents. Fifteen years later, the now-grown Cataleya (Zoe Saldana), who is named for a Colombian orchid, works as a contract killer for her Chicago-based uncle (Cliff Curtis). Leaving a lipstick drawing of her namesake on every victim, Cataleya carries out her assignments with cold, frightening efficiency and dreams of avenging her family. When Cataleya witnesses her parents' death, she goes on to become an expert assassin and sets out to seek revenge against the culprits.