Chaméléon yitwa Rango, wari usanzwe ari inyamaswa y’iwabo mu nzu, aba afite inzozi zo kuba intwari. Nyuma y’impanuka imutandukanya n’abamurera, asanga ari wenyine mu butayu bwa Mojave. Aho, ahura n’umujyi w’inyamaswa witwa Dirt, wugarijwe n’amapfa n’akajagari.

Rango yihindura intwari y’ikirenga, avuga ko ari umurinzi w’umujyi, maze ahabwa akazi ko kuba Sheriff. Ariko uko ibintu bigenda birushaho gukomera—ibura ry’amazi, ibinyoma by’abayobozi, n’abanzi bafite intwaro—Rango atangira kwibaza niba koko ari intwari cyangwa ari umukinnyi w’ikinamico gusa.

Ni inkuru y’urugendo rwo kwiyakira, kwigira intwari mu buryo bw’ukuri, no gusobanukirwa ko ubutwari butava mu ntwaro, ahubwo buva mu mutima.